瑞典南部马尔默多发性硬化症移民的患病率和疾病残疾
Lucía Alonso-Magdalena1, Olga Carmona I Codina2, Elisabet Zia3
1Department of Neurology, Skåne University Hospital and Department of Clinical Sciences, Lund University, Lund, Sweden.
Clinical neurology and neurosurgery
|March 29, 2024
概括
在马尔默的第一代移民中,多发性硬化症 (MS) 的患病率较低,但与斯堪的纳维亚人相比,非西方群体的疾病进展更严重. 这项研究强调了不同人群中多发性硬化症进展的潜在差异.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是年轻人残疾的主要原因.
- 移民研究表明,MS残疾的种族差异.
- 瑞典移民中的疾病进展仍未得到充分研究.
研究的目的:
- 为了确定在瑞典马尔默的第一代移民中MS的流行率.
- 为了比较移民群体和本地人口之间的多发性硬化症严重程度.
主要方法:
- 纳入截至2010年12月31日马尔默诊断患有多发性硬化症的所有个人.
- 根据出生国家对病例的分类:斯堪的纳维亚,西方和非西方.
主要成果:
- 原始的MS患病率为移民的100/100,000,斯堪的纳维亚人的154/100,000,西方移民的123/100,000,非西方移民的76/100,000.
- 虽然初始严重程度得分 (MSSS) 没有显著差异,但调整后的分析显示,非西方移民的疾病严重程度在统计上显著增加 (MSSS平均差异为1.7,p=0.030).
- 在各组之间,在诊断或治疗开始的时间内没有观察到显著差异.
结论:
- 与斯堪的纳维亚人口相比,马尔默的第一代移民的MS总体患病率较低.
- 非西方移民经历的MS比斯堪的纳维亚人更严重的疾病过程.
- 研究结果表明,多发性硬化症严重程度的潜在差异受地理来源的影响.
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