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Updated: Jun 29, 2025

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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维门丁通过与核囊蛋白相互作用来抑制小反动物瘟疫病毒的复制

Long Xu1, Jingjing Ren2, Lingxia Li2

  • 1College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, China; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, China; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China.

Virology
|March 29, 2024
PubMed
概括

小动物瘟疫病毒 (PPRV) 核体 (N) 蛋白与宿主蛋白维门丁相互作用. 维门丁招募NEDD4L,导致N蛋白降解和抑制PPRV复制.

关键词:
核体蛋白质是一种核体蛋白质.小反动物病毒的瘟疫.乌比奎丁是一种存在的药物.在Vimentin中,使用了Vimentin.病毒复制是病毒的复制.

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Leaky Scanning02:28

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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