乳酸细菌与Polygonatum sibiricum桑素之间的相互作用及其对微封装共递的应用
Jiayuan Luo1, Mingjie Jia1, Xue Yang1
1College of Life Sciences, Northeast Forestry University, Harbin 150040, PR China.
Food chemistry
|March 29, 2024
概括
波利格纳 (Polygonatum sibiricum) 的素 (PSS) 增强了L. casei和L. bulgaricus的生长和新陈代谢. 与PSS一起的共同微封装改善了益生菌的存活率和潜在的低血糖效应.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 食品科学 食品科学 食品科学
背景情况:
- 像L.casei和L.bulgaricus这样的益生菌是有益的微生物.
- 波利格纳 (Polygonatum sibiricum) 的酸盐 (PSS) 是具有潜在健康益处的生物活性化合物.
- 益生菌的活力和有效性在储存和胃肠道运输过程中可能会受到损害.
研究的目的:
- 研究L.casei,L.bulgaricus和PSS之间的相互作用.
- 为了探索PSS的前生物潜力.
- 为增强益生菌和PSS稳定性和输送开发一个共同微囊的输送系统.
主要方法:
- 将PSS添加到益生菌培养中,并分析生长和新陈代谢.
- 液体染色学 - 质谱学 (LC-MS) 用于沙素分析.
- 益生菌变化的代谢分析.
- 在体外评估低血糖活性 (α-葡萄糖酶抑制,HepG2细胞测试).
- 配微封装使用和异多氧糖.
主要成果:
- PSS (1%) 添加加速了益生菌的生长和新陈代谢,特别是在组合培养中,这表明了益生菌的作用.
- 在LC-MS检测中,发现了PSS氨酸成分的显著差异.
- 代谢分析显示PSS显著改变了益生菌代谢物.
- 益生菌-PSS组合表明增强了低血糖潜力.
- 同微封装系统在模拟的胃肠液中表现出优越的耐药性,确保有针对性的输送到小肠.
结论:
- PSS作为一种益生菌,促进益生菌的生长和代谢.
- 益生菌与PSS的共同微缩,使用和异多氧糖,提高了它们的稳定性和输送.
- 综合系统有望改善低血糖效应和益生菌疗效.
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