身体活动与胃食道逆流性疾病风险之间的关联:系统性审查和元分析
Chuting Yu1, Tinglu Wang1, Ye Gao1
1Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 200433, China; National Clinical Research Center for Digestive Diseases (Shanghai), Shanghai 200433, China.
Journal of sport and health science
|March 29, 2024
概括
定期体力活动 (PA) 显著降低了胃食道逆流病 (GERD) 的风险. 每周进行150分钟的PA可能会降低GERD的患病率,特别是在老年人和吸烟者中.
科学领域:
- 胃肠病学 胃肠病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 生活方式因素对于管理胃食道逆流性疾病 (GERD) 是至关重要的.
- 以前对体力活动 (PA) 和GERD的研究产生了相互矛盾的结果.
- 进行了系统审查和元分析,以澄清PA和GERD之间的关联.
研究的目的:
- 系统地审查和对现有关于身体活动和GERD之间的关系的研究进行元分析.
- 为了确定与身体活动水平相关的症状性GERD的患病率.
- 调查潜在的亚组差异和剂量-反应关系.
主要方法:
- 在6个数据库中进行了全面的文献搜索,直到2023年1月.
- 使用随机效应模型进行了对GERD相对风险 (RR) 的元分析.
- 进行了亚组和剂量反应分析,以探索PA的变化和累积效应.
主要成果:
- 分析包括33项研究,涉及242,850名参与者.
- 在PA和症状性GER (RR=0.74) 或GERD (RR=0.80) 之间发现了显著的负面关联.
- 酸盐表现出一种保护作用,特别是在老年人和吸烟者身上,每周150分钟与72.09%的GERD风险降低有关.
结论:
- 高水平的体力活动与降低GERD风险有关.
- 在老年人和吸烟者中,PA对GERD的保护作用明显.
- 达到建议的每周150分钟的PA可能会大大降低GERD的患病率.
相关概念视频
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
313
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
313
Gastroesophageal Reflux Disease II: Clinical Features and Management
78
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
78
Barrett Esophagus-I: Introduction
90
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
90
Barrett Esophagus-II: Clinical Manifestations and Management
141
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
141
Esophageal Strictures-I: Introduction
90
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
90
Peptic Ulcer Disease I: Introduction
168
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
168


