一种浮动的3D打印多药丸配方,用于同时服用和持续释放抗高血压药物
Paola Zgouro1, Orestis L Katsamenis2, Thomas Moschakis3
1Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124, Thessaloniki, Greece.
International journal of pharmaceutics
|March 29, 2024
概括
含有三种抗高血压药物的3D打印多药丸显示了12小时的长时间胃保留和持续释放,解决了老年患者的多药学挑战.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 3D打印应用 3D打印应用
背景情况:
- 在老年患者中常见的多种药物,导致注射错误和不便.
- 高血压治疗通常需要多种活性药物成分 (API),加剧了多种药物.
- 现有的药物输送方法可能无法优化治疗慢性病的多种API的管理.
研究的目的:
- 开发和表征新型浮式空洞形剂型 (多种药) 用于持续释放三种抗高血压药物.
- 使用体外和体外模型评估3D打印多种药丸的胃保留能力.
- 评估体外药物释放特征,并预测纳入的API的药物动力学参数.
主要方法:
- 化沉积建模3D打印被用于制造含有迪尔提亚泽姆,普罗巴诺洛尔和甲酸的形多药片.
- 在实验室中,浮力和聚合 ("Cheerios效应") 被评估为长时间的胃保留.
- 活体研究使用猪胃模型来评估多药丸的粘附和保留.
- 在12小时内进行了体外溶解测试.
- 基于卷积的建模预测了药理动力学参数.
主要成果:
- 3D打印的多种药丸在体外表现出由于浮力和"鼓舞人效应"而延长了12小时的保留时间.
- 外体猪胃模型证实了剂型的显著聚合,粘附和保留.
- 试验室溶解显示,在12小时内,diltiazem (99.9%) 和propranolol (93.52%) 的高释放率,以及hydrochlorothiazide (65.22%) 的部分释放率.
- 预测的药物动力学参数与之前报告的数据相似.
结论:
- 3D打印的浮动形多药丸为高血压的多药管理提供了有前途的方法.
- 这种"快乐的效应"和浮力机制有效地增强了胃的保留.
- 该配方提供了多种抗高血压API的持续释放,可能改善患者的服药性和治疗结果.
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