环境中的铜暴露,胎盘亡和流产
Jingsong Zhao1, Zhongyan Xu1, Xiaoqing Wang2
1Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, 610041, China; Research Center for Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China.
Environmental pollution (Barking, Essex : 1987)
|March 29, 2024
概括
环境中的铜暴露可以通过诱导称为cuproptosis的胎盘细胞死亡而导致流产. 这项研究表明,即使是低剂量也会破坏胎盘功能,导致小鼠流产. 一种 cuproptosis 抑制剂可以防止这些影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 铜污染是一个全球性问题,具有潜在的生殖毒性.
- 铜,一种依赖铜的细胞死亡,最近被确定.
- 环境中的铜暴露对胎盘亡和流产的影响仍然未被探索.
研究的目的:
- 调查铜暴露的环境剂量是否会诱导胎盘亡和流产.
- 为了阐明铜诱导的胎盘亡的潜在机制.
- 评价 cuproptosis 抑制剂对铜诱导的生殖毒性的治疗潜力.
主要方法:
- 孕妇小鼠在环境相关剂量中暴露于化铜 (CuCl2).
- 对胎盘组织进行分析,以检测亡标记物,TCA循环中断,蛋白质毒性压力和铁硫蛋白质损失.
- 研究微RNA (mmu-miR-3473b) 参与铜诱导的胎盘亡.
- 用cuproptosis抑制剂 (TTM) 治疗以评估其保护作用.
主要成果:
- 暴露在1.3毫克/千克/天的铜中,通过引起小鼠的胎盘亡,诱导流产.
- CuCl2暴露破坏了TCA循环,增加了铜离子的进口,并导致Fe-S集群蛋白质的损失.
- 铜暴露降低了mmu-miR-3473b的调节,通过表观遗传学调节了胎盘亡.
- 用TTM治疗抑制了胎盘缩并降低了流产率.
结论:
- 环境中的铜暴露可以通过胎盘亡导致流产.
- 铜诱导的生殖毒性包括TCA循环中断和蛋白质毒性压力.
- 向铜死提供了一个潜在的策略,以防止铜诱导的怀孕流产.
相关概念视频
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
02:07Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
01:27Ovarian Cycle
1.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.2K