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眼睛薄膜的物理和机械特性:系统的审查和元分析
Mitra Farahmandnejad1, Shohreh Alipour1, Ali Nokhodchi2
1Department of Drug & Food Quality Control, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Drug discovery today
|March 29, 2024
概括
眼膜薄膜为将药物输送到眼睛提供了一个有前途的方法. 聚合物类型和增塑剂显著影响膜的特性,如粘膜粘合和胀,这对于有效的眼睛配方至关重要.
科学领域:
- 眼科和制药科学 眼科和制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 眼部药物输送面临诸多挑战,包括快速清除和低生物可用性.
- 眼膜薄膜正在成为一种新的药物输送系统,以克服这些局限性.
研究的目的:
- 综合审查和分析眼膜薄膜的物理和机械性能.
- 了解聚合物类型和增塑剂对这些特性的影响,以优化眼部药物配方.
主要方法:
- 对68项研究进行了系统审查,分析了336种眼膜薄膜配方.
- 薄膜分类为基于天然聚合物,基于合成聚合物和组合聚合物类型.
- 研究关键的物理和机械性质:粘膜粘合,水分动态,pH值,胀和延长.
主要成果:
- 聚合物的类型显著影响了粘粘度,吸水/损失比率,pH值,胀指数和延长百分比.
- 在天然,合成和组合聚合物子组中确定了这些特性之间的显著关系.
- 发现可塑剂会影响延长百分比,粘膜粘合力,胀指数和吸水/损失比率.
结论:
- 眼睛的薄膜特性高度依赖于选择的聚合物和可塑剂.
- 了解这些关系对于设计和优化眼部药物输送系统至关重要.
- 聚合物和塑化剂的战略选择可以导致具有改善眼部药物输送所需特征的配方.
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