多种挥发性有机化合物暴露对美国成年人口血液学参数的单一和混合影响
Yan Zhuang1, Laifu Li1, Yanqi Zhang1
1Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chemosphere
|March 29, 2024
概括
这项研究表明,暴露于挥发性有机化合物 (VOC) 对血液细胞计数产生影响,像BMA这样的特定化合物显示出负相关性. 组合的VOC暴露也会影响血液学参数,突出显示了公众健康的担忧.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 血液学 血液学 血液学
背景情况:
- 有限的研究存在于挥发性有机化合物 (VOC) 对血液学参数的综合影响.
- 之前的研究主要集中在单一的VOC暴露.
研究的目的:
- 研究VOCs对血液学参数的单一和综合影响.
- 探索吸烟状态对这些关系的影响.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 的四个周期的数据.
- 采用了加权多重线性回归,加权量子素和 (WQS) 和贝叶斯内核机器回归 (BKMR) 模型.
- 使用最少绝对收缩和选择操作员 (LASSO) 识别的关键VOC.
主要成果:
- N-乙-S-() -l-氨酸 (BMA) 与白血细胞 (WBC),红血细胞 (RBC),淋巴细胞和中性粒细胞数量有显著的负相关性.
- 组合的VOC暴露,特别是在70个百分点以上的水平,与较低的红细胞计数有关,BMA被确定为主要贡献者.
- 吸烟状态显著改变了VOC和血液学参数之间的关联.
结论:
- 暴露于单个和组合的VOC会影响血液学参数,这表明潜在的血液毒性和促炎作用.
- 这些发现强调了缓解VOC暴露的公共卫生重要性,以保护血液系统.
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