老年人多重污染物暴露与甲状腺激素之间的关联:中国的一项横截面研究
Bin Han1, Lulu Wang1, Xiu Wang2
1State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China.
Environmental research
|March 29, 2024
概括
这项研究研究了144种环境化学物质如何影响老年人甲状腺激素水平. 金属,PAHs,SPs,PCB和除草剂被确定为关键的破坏性物质,强调需要了解化学物质的组合暴露.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 环境化学物质与甲状腺平衡破坏有关.
- 以前的研究往往侧重于单一的化学组,忽视了组合效应.
- 甲状腺激素对整体健康至关重要,特别是在老年人群中.
研究的目的:
- 研究144种环境污染物对甲状腺平衡生物标志物的独立和综合作用.
- 确定与老年人甲状腺激素障碍相关的特定化学组.
- 为在风险评估和公共卫生战略中优先考虑化学品提供见解.
主要方法:
- 使用多重线性回归 (MLR) 进行单个污染物分析.
- 在多污染物分析中使用弹性净回归和贝叶斯核机器回归 (BKMR).
- 评估了来自十个类别的144种化学物质和甲状腺生物标志物 (TSH,tT4,ft4,tT3,ft3) 之间的关联.
主要成果:
- MLR确定了41种与甲状腺激素水平显著相关的化学物质.
- BKMR模型突出了关键化学组:金属用于TSH,PAH,SP和PCB用于tT4,除草剂和SP用于tT3.
- 这项研究揭示了环境化学物质对甲状腺功能的显著综合作用.
结论:
- 多种环境化学物质,特别是金属,PAHs,SPs,PCB和除草剂,破坏甲状腺平衡.
- 了解这些污染物的综合影响对于准确的风险评估至关重要.
- 这项研究有助于在监管行动和公共卫生干预中优先考虑化学组.
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