美国老年人中粮食不安全,炎症和免疫功能:健康与退休研究的发现
Abeer A Aljahdali1, Elizabeth Ludwig-Borycz2, Cindy W Leung3
1Department of Clinical Nutrition, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Nutritional Sciences, University of Michigan, Ann Arbor MI 48109, USA.
老年人的粮食不安全 (FI) 与更高的炎症和较差的免疫功能有关. 解决FI可能会改善这个脆弱人群的健康结果.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
背景情况:
- 粮食不安全 (FI) 是老年人面临的一个重大公共卫生问题.
- FI与不良的心血管结果有关,可能由系统性炎症介导.
- 很少有研究探讨了老年人群中FI和炎症标志物之间的关系.
研究的目的:
- 调查家庭粮食不安全与各种炎症和免疫功能生物标志物之间的联系.
- 分析来自50岁以上美国成年人全国代表性样本的数据.
主要方法:
- 利用了3924名健康与退休研究 (HRS) 参与者的数据.
- 使用简单形式的粮食安全调查模块评估家庭FI.
- 从血液样本中测量炎症标记物 (例如hs-CRP,IL-6) 和免疫标记物 (例如CMV).
- 采用多变量逻辑和线性回归模型,调整社会人口统计因素.
主要成果:
- 18.8%的老年人经历过粮食不安全.
- FI与炎症升高和免疫功能受损有关 (p < 0.05).
- 具体关联包括高hs-CRP,IL-6,IL-1Ra,TGFß-1和CMV血清阴性在食物不安全的个人.
结论:
- 粮食不安全与系统性炎症和老年人免疫功能下降有关.
- 针对该人口群体减少FI的公共卫生举措至关重要.
- 减少FI可能会改善老年人的健康和福祉.
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