准则编号 准则编号 448: 预防Rh D类免疫接种
Karen Fung-Kee-Fung1, Karen Wong1, Jennifer Walsh2
1Ottawa, ON.
概括
常规的RhD免疫预防显著降低了RhD阴性孕妇的RhD与免疫接种风险. 本指南更新了关于使用Rho (D) 免疫球蛋白 (RhIG) 的建议,包括D变体和胎儿Rh型化.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 在怀孕期间,Rh D 与免疫接种存在风险.
- 预防策略对于母亲和胎儿的健康至关重要.
研究的目的:
- 为预防怀孕期间的RhD与免疫接种提供最新的建议.
- 为医疗保健提供者提供有关适当使用Rho (D) 免疫球蛋白 (RhIG) 的指导.
主要方法:
- 从2000年1月到2019年11月的试验和观察研究的系统审查.
- 包括灰色文献和先前研究.
- 证据的质量和建议的强度使用修改后的GRADE方法进行评估.
主要成果:
- 常规的产后和产前RhD免疫预防有效地降低了RhD与免疫的风险.
- 该指南确定了受益于RhIG的孕妇,优化其使用并最大限度地减少潜在的不良影响.
结论:
- 更新的建议涉及RhD变异和用于胎儿RhD类型的无细胞DNA (cfDNA) 的使用.
- 该指南强调及时给予RhIG以减轻所有免疫风险.
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