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多巴胺D2受体调节运动相关的对皮质刺激/抑制和运动技能获得的影响
Dylan Curtin1, Eleanor M Taylor1, Mark A Bellgrove1
1School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria 3800, Australia.
概括
运动通过影响多巴胺D2受体和大脑激发-抑制平衡来促进运动学习. 阻断D2受体与硫胺损害了技能获得,证实了它们在运动增强的运动学习中的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 药理学 药理学是指药理学的学科.
背景情况:
- 运动可以提高健康个体和神经疾病患者的运动技能学习.
- 多巴胺D2受体和皮质刺激-抑制 (E:I) 平衡与运动驱动的运动学习有关.
- 目前,缺乏将这些因素联系在一起的因果关系证据.
研究的目的:
- 调查多巴胺D2受体活性在调节运动引起的皮质E:I平衡变化和随后的运动技能的获得中的因果作用.
- 测试假设D2受体调节E:I平衡转移决定了运动后运动技能学习的程度.
主要方法:
- 22名健康参与者接受了双脉冲跨磁刺激 (TMS),以测量运动诱导的皮层刺激和抑制变化.
- 参与者在随机,双盲,安慰剂控制的设计下学习了顺序视觉同度针任务 (SVIPT).
- 研究了D2受体阻塞与硫化物 (800毫克) 与安慰剂对运动学习和E:I平衡的影响.
主要成果:
- 运动技能的获得受到D2受体活性与E:I平衡转移之间的相互作用的显著影响.
- 较差的运动技能学习与E:I平衡的减弱转变相关,当D2受体被硫化物阻断时.
- 在安慰剂条件下没有观察到这种相互作用,突出显示了D2受体的特定作用.
结论:
- 运动培养的运动技能获得因果关系依赖于运动皮质电路内的多巴胺D2受体活性.
- 皮质E:I平衡的D2受体调节是运动对运动学习的益处的关键机制.
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