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食物蛋白诱导肠球炎综合征 (FPIES) 的异质性

Masayuki Akashi¹, Sachiko Kaburagi¹, Naoki Kajita²

¹Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Allergology international : official journal of the Japanese Society of Allergology

|March 29, 2024

概括

食物蛋白诱导肠道炎综合征 (FPIES) 呈现出不同患者的特征. 本综述提出了四个不同的FPIES疾病实体,以更好地了解其异质性和病理生理学.

科学领域:

过敏和免疫学过敏和免疫学
胃肠病学胃肠病学
儿科儿科儿科

背景情况:

食物蛋白诱导肠肠炎综合征 (FPIES) 是一种非IgE介导的胃肠道食物过敏.
2017年的国际指导方针促进了全球患者的比较,揭示了FPIES特征的显著异质性.

研究的目的:

突出FPIES特征的异质性,包括触发性食物,发病年龄和地理差异.
根据年龄和假定的病理生理学,提出将FPIES细化分为四个不同的疾病实体的分类.

主要方法:

根据FPIES的2017年国际共识指南,审查现有文献和患者数据.
分析临床特征,触发性食物,发病年龄和地理分布,以确定异质性的模式.

主要成果:

在FPIES中发现的异质性触发食物,发病年龄,地理位置和症状.
提出了四种FPIES疾病实体:儿童急性FPIES,成人急性FPIES,慢性FPIES和早期发病的新生儿FPIES.
早期发病的新生儿FPIES可能在病理生理学和诊断标准的满足方面有所不同,可能被误诊为死性肠球炎.

结论:

FPIES是一种异质的疾病,需要超出当前诊断标准的细微了解.
识别不同的FPIES实体,特别是早期发作的新生儿FPIES,对于准确的诊断和管理至关重要.
对FPIES异质性和病理生理学的进一步研究对于改善儿童和成人群体的患者护理至关重要.

关键词:

成年人的FPIES是FPIES.长期的FPIES是一种慢性FPIES.食物蛋白引起的肠球炎综合征 (FPIES)死性肠球炎 (NEC) 是一个疾病.非IgE介导的食物过敏

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