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[关于直肠腺癌全新辅助治疗的最新情况]

Maroussia Medioni¹, Baptiste Cervantes¹, Florence Huguet²

¹Sorbonne université, hôpital Saint-Antoine, AP-HP, service d'oncologie médicale, 75012 Paris, France.

Bulletin du cancer

|March 29, 2024

概括

对直肠癌的全新辅助治疗显示出有前途,改善了生存率和反应率. 然而,仔细选择患者至关重要,以平衡治疗效益与局部区域复发等风险.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
胃肠道瘤学胃肠道瘤学

背景情况:

自2021年以来,全新辅助治疗 (TNT) 已成为直肠癌管理的重大进展.
像RAPIDO和PRODIGE-23这样的关键试验已经证明,TNT的无进展生存率和病理完整反应率有所改善.

研究的目的:

综合最近关于直肠癌新辅助治疗的数据.
分析RAPIDO和PRODIGE-23试验的长期结果.
将这些发现与新兴的降级战略联系起来.

主要方法:

来自主要临床试验的数据的审查和综合,包括RAPIDO,PRODIGE-23,OPRA和PROSPECT.
对最新的生存数据和局部区域复发率的分析.
在手术和放射治疗方法中评估降级可能性.

主要成果:

拉皮多试验的更新的5年生存数据表明,与对照组 (8.1%) 相比,实验组 (11.7%) 的局部区域复发风险更高.
PRODIGE-23试验证实了TNT的益处,显示了整体存活率的显著改善.
OPRA和PROSPECT试验支持TNT与诱导化疗,展示了手术和放射治疗降级的潜力.

结论:

对于直肠癌患者来说,TNT提供了显著的生存和反应益处.
长期数据表明,需要仔细选择患者,以优化TNT的疗效,并最大限度地降低复发风险.
未来的努力应该集中在识别那些从TNT中受益最多的患者,而不是那些适合治疗降级策略的患者.

关键词:

结直肠癌 (cancer du rectum) 是一种直肠癌.化学疗法或放射疗法化学辐射疗法化学辐射疗法缓和局势升级的战略预言人23-第二十三节这是一个快速的速度.这是直肠癌.这是一个不升级战略.总的新辅助治疗治疗.治疗新辅助剂总量

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