含有三甘油的奇多纳米凝:揭示了细胞毒性,抗氧化能力和抗菌活性
Khatereh Asadi1, Reza Heidari2, Mehrdad Hamidi3
1Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Nanotechnology, School of Advanced Medical Science and Technology, Shiraz University of Medical Sciences, Shiraz, Iran; Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran.
International journal of biological macromolecules
|March 29, 2024
概括
装有三甘油的奇多纳米凝 (TNG-Ngs) 开发用于改善药物输送. 这些TNG-Ngs表现出增强的抗菌和抗氧化特性,降低了毒性,为与氧化相关的疾病提供了有前途的纳米配方.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 三甘油 (TNG) 是一种强大的氧化 (NO) 释放剂.
- 高剂量TNG的使用与不良并发症有关.
- 基托纳米凝 (Ngs) 为改善药物输送提供了一个潜在的平台.
研究的目的:
- 为了合成含有三甘油的奇托纳米凝 (TNG-Ngs).
- 为了评估TNG-Ngs的物理化学特性,生物相容性和有效性.
- 研究TNG-Ngs作为一种新的纳米配方,用于治疗NO依赖性疾病的潜力.
主要方法:
- 使用离子凝技术制造了TNG-Ngs.
- 使用FT-IR,zeta-potential和DLS进行了物理化学性能评估.
- 生物相容性,抗氧化剂和抗菌活性使用MTT,LDH,ROS,LPO和针对S. aureus,大肠杆菌,MRSA和VRE的微生物测试来评估.
主要成果:
- 成功合成了TNG-Ngs,颗粒大小为96.2nm,泽塔电位为-1.1mV.
- 封装效率和负载能力分别为71.1%和2.3%.
- 与自由TNG相比,TNG-Ngs显著增强了抗菌和抗氧化活性,改善了生物相容性和降低了细胞毒性.
结论:
- TNG-Ngs代表了一种具有增强治疗潜力的新型纳米配方.
- 开发的TNG-Ngs表现出优越的抗菌和抗氧化特性.
- 这种纳米配方可能为治疗NO依赖性疾病提供更安全,更有效的方法.
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