在COVID-19时代,可解释的人工智能分析甲疗法在宫癌中增加了收件
Colton Ladbury1, Nicholas Eustace1, Ari Kassardjian1
1Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA.
Brachytherapy
|March 29, 2024
概括
机器学习确定了影响腕治疗的因素,促进了宫癌患者的使用. 随着时间的推移,支臂治疗的利用率有所增加,并且没有受到COVID-19的显著影响.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 机器学习 机器学习
背景情况:
- 支臂疗法对于治疗局部晚期宫癌 (LACC) 是至关重要的.
- 文献表明,许多LACC患者没有获得推的支臂治疗增强剂.
- 支臂疗法获取和利用的差异需要调查.
研究的目的:
- 对LACC患者来说,增强支臂疗法利用率的差异.
- 使用机器学习 (ML) 识别影响支臂疗法增强接收的因素.
- 为了评估COVID-19大流行对支臂疗法增强利用的影响.
主要方法:
- 利用国家癌症数据库识别LACC患者 (2004-2020年).
- 训练了五个ML模型,以预测brachytherapy增强接收.
- 为了模型的可解释性,采用了夏普利添加式解释 (SHAP).
- 对2019-2020年间诊断的患者进行了分分析,以评估COVID-19的影响.
主要成果:
- 总共有37,564名LACC患者被分析;59.3%的患者整体接受了支臂治疗.
- 在2019-2020年队列中,76.4%的患者接受了支臂疗法.
- 整体队列中的关键预测因素包括诊断年,阶段,年龄和保险.
- 在COVID队列中,FIGO阶段,年龄,保险和医院类型是最具预测性的.
- 在放射治疗期间,73.1%的COVID-19患者接受了支臂疗法.
结论:
- 支臂疗法增强利用率显示了一种逐渐增长的趋势.
- COVID-19大流行并没有显著改变支臂疗法增强利用趋势.
- ML可以识别未充分利用支臂治疗的患者群体,为改进获取机会的策略提供信息.
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