替代疗法的心血管安全性在男性:一个更新的系统性审查和元分析
Giovanni Corona1, Giulia Rastrelli2, Clotilde Sparano3
1Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy.
替代疗法 (TRT) 不会增加心血管风险. 对随机对照试验的元分析发现,TRT和安慰剂组之间主要心血管不良事件没有显著差异.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 替代疗法 (TRT) 的心血管 (CV) 安全性仍在争论中.
- 一些研究表明,TRT可能会增加心房动 (AF) 的风险.
研究的目的:
- 系统地审查和元分析与TRT相关的CV风险.
- 评估TRT和AF发病率之间的关系.
主要方法:
- 在Medline,Embase和Cochrane数据库中进行了广泛的文献搜索.
- 包括关于TRT CV安全性的安慰剂对照随机试验 (RCT).
- 对内源性水平和AF的基于人口的研究分析.
主要成果:
- 分析了106项研究,其中包括8126名TRT受试者和7310名安慰剂受试者.
- 在TRT和安慰剂之间,主要的不良心血管事件没有显著差异.
- 在大多数研究中,使用TRT并没有显著增加AF发病率.
结论:
- 现有数据表明,TRT是安全的.
- TRT与心血管风险增加无关.
- 没有发现内源性丸激素水平和AF之间的关系.
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