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作为人类癌症新型预后生物标志物的长非编码RNA LINC-PINT:元分析和机器学习

Jie Lin¹, Li Chen², Dan Zhang³

¹Department of Hepatobiliary and Pancreatic Surgery, Jilin University Second Hospital, Changchun, Jilin, China.

Scientific reports

|March 30, 2024

概括

长跨基因非蛋白编码RNA (LINC-PINT) 的上调与更好的癌症存活率有关. 这项研究证实了LINC-PINT作为各种人类癌症的潜在预后生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

长跨基因非蛋白质编码RNA,P53诱导转录 (LINC-PINT) 表达在癌症中有所不同,但其预后作用仍在争论中.
了解LINC-PINT对癌症预后的影响对于开发新的生物标志物至关重要.

研究的目的:

综合评估LINC-PINT在人类癌症中的预后意义.
调查LINC-PINT的潜在致癌机制.

主要方法:

系统的文献综述 (PubMed,Embase,Cochrane,科学网) 这是一个很好的方法.
对8项涉及911名患者的研究进行了元分析.
生物信息学分析和体外验证 (qRT-PCR).

主要成果:

LINC-PINT上调与更好的患者存活率有关 (P=0.002).
下调与晚期瘤阶段 (P=0.04) 和差异化 (P=0.03) 相对应.
LINC-PINT表达与瘤突变负担 (TMB) 和微卫星不稳定性 (MSI) 相联系.

结论:

失调的LINC-PINT表达与各种癌症的关键临床预后和病理特征有关.
作为各种人类恶性瘤的新预后生物标志物,LINC-PINT显示出显著的潜力.
对LINC-PINT机制的进一步研究可以阐明其在瘤发生中的作用,并指导治疗策略.

关键词:

癌症癌症癌症癌症在LINC-PINT上,我们可以看到.长的非编码RNA是什么?预后生物标志物预后生物标志物

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