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Updated: Jun 29, 2025

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通过Poly ADP-ribose聚合酶 1 的合作核酸结合

Manana Melikishvili1, Michael G Fried2, Yvonne N Fondufe-Mittendorf3

  • 1Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA.

Scientific reports
|March 30, 2024
PubMed
概括

聚 (ADP) - 核糖聚合酶1 (PARP1) 结合单链DNA和RNA,具有积极的合作性,其功能独立于其催化域. 核酸的二次结构影响了PARP1的结合史泰基度,揭示了它的多功能连接体识别.

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