在转移性乳腺癌中进行全食物,植物性随机对照试验:可行性,营养和患者报告的结果
Erin K Campbell1, Thomas M Campbell2, Eva Culakova3
1Department of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Blvd, Rochester, NY, 14642, USA. erin_campbell@urmc.rochester.edu.
Breast cancer research and treatment
|March 30, 2024
概括
对于转移性乳腺癌 (MBC) 的女性来说,全食,植物性 (WFPB) 饮食是可行的. 这种饮食干预通过增强认知功能和减少疲劳来改善生活质量.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 生活质量研究 研究 生命质量研究
背景情况:
- 生活质量 (QOL) 是患有转移性乳腺癌 (MBC) 的女性的一个关键结果,直接影响了生存率.
- 认知障碍,疲劳和体重增加是对MBC患者的QOL产生负面影响的重要因素.
研究的目的:
- 为了评估全食,植物性 (WFPB) 饮食干预的可行性.
- 为了确定WFPB促进减肥的饮食是否可以改善MBC妇女的QOL.
主要方法:
- 随机对照试验,女性患有MBC (2:1比) 被分配给WFPB饮食或常规护理8周.
- 干预包括每周教育和提供WFPB餐;通过患者报告的措施和食物记录来评估结果.
- 对基线值进行控制的协差分析,以评估WFPB饮食的影响.
主要成果:
- 在干预组中观察到WFPB饮食的高度坚持 (94.3%).
- 与对照组相比,WFPB组的认知功能 (p=0.040) 和情感幸福感 (p=0.016) 显著改善.
- 世界粮食计划署的饮食导致疲劳严重程度 (p=0.047) 和疲劳最严重的情况 (p=0.011) 显著减少.
结论:
- 实施显著的饮食变化,如WFPB饮食,对于患有MBC的女性来说是可行的.
- 一种WFPB饮食可以通过减轻与治疗相关的症状,如疲劳和认知问题来提高QOL.
- 需要进一步的研究来探索WFPB饮食在这个人群中的长期益处.
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