在腹腔透析患者中,较长的血清时间与较低的死亡风险有关:多中心回顾性队列研究
Zhihao Huo1,2, Dehui Liu3, Peiyi Ye4
1Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
BMC nephrology
|March 30, 2024
概括
在第一年,在较长时间内保持血清在目标范围 (1.13-1.78 mmol/L) 中,与腹腔透析患者的死亡风险降低有关. 这项研究强调了控制对改善患者治疗结果的重要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 腹腔透析 (PD) 患者血清含量与死亡率之间的关联尚未得到充分证实.
- 这项研究调查了中国PD人群中血清时间范围和死亡风险之间的联系.
研究的目的:
- 评估血清时间范围与中国PD患者全因死亡率之间的关联.
- 评估维持血清在目标范围内 (1.13-1.78 mmol/L) 对患者结局的影响.
主要方法:
- 这是一项多中心的回顾性队列研究,涉及1915名PD患者.
- 血清在范围内的时间计算为第一年目标范围内的数月.
- 考克斯比例危险回归和竞争风险模型被用于分析与死亡率,心血管死亡率和PD退出的关联.
主要成果:
- 较长的血清时间范围与所有原因死亡率 (aHR,0.83),心血管死亡率 (aHR,0.87) 和PD退出风险 (aHR,0.89) 的降低显著相关.
- 观察到的关联在竞争风险分析中保持稳定.
- 没有人口或临床因素改变了血清时间与死亡率之间的关系.
结论:
- 在PD开始后的第一年,达到更长的血清时间范围与较低的全因和心血管死亡率有关.
- 维持血清水平在1.13-1.78 mmol/L之间对于改善PD患者的生存率至关重要.
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