对 pT3N0M0食道癌进行手术的辅助治疗模式
Su Pei1, Jiang-Qiong Huang1, Huan-Wei Liang1
1Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.
概括
辅助治疗没有改善食道状细胞癌患者手术后的生存率. 然而,化学放射治疗和化疗改善了食道腺癌患者的整体存活率.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 食道癌的分期对于治疗决策至关重要.
- 对于pT3N0M0食道癌的手术后辅助疗法需要进一步调查.
- 新辅助化学放射治疗没有给研究队列.
研究的目的:
- 评估辅助治疗模式对患有 pT3N0M0食道癌后食道切除术的患者生存的影响.
- 为了比较单独的手术和各种辅助治疗方式之间的整体存活率 (OS).
- 根据食道癌组织学来确定辅助疗法的差异效应.
主要方法:
- 在2000年至2020年期间,对445名被诊断为pT3N0M0食道癌的患者进行了回顾性分析.
- 来自监测,流行病学和最终结果 (SEER) 数据库的数据.
- 卡普兰-梅尔分析被用来比较不同治疗组的整体存活期 (OS).
主要成果:
- 对于状细胞癌,辅助化疗或放射治疗,化疗或放射治疗,与单独手术相比,在 OS 上没有显著差异.
- 对于腺癌,辅助化学放射治疗 (HR=0.51,P<0.001) 和化疗 (HR=0.61,P=0.006) 与单独手术相比,显著改善了OS.
- 在腺癌患者中,辅助放射治疗没有显著改变OS (HR=0.81,P=0.495).
结论:
- 辅助疗法不能提高pT3N0M0食道状细胞癌患者的生存结果接受手术.
- 建议使用辅助化学放射治疗和化疗,以改善 pT3N0M0食道腺癌患者手术后的生存率.
- 组织学亚型是确定食道癌辅助治疗疗效的关键因素.
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