激素替代疗法对慢性鼻炎治疗的影响
Kevin Herrera1, Miti Parikh1, Sahiti Vemula1
1Keck School of Medicine, University of Southern California, Los Angeles, California, U.S.A.
The Laryngoscope
|March 30, 2024
概括
慢性鼻炎 (CRS) 的老年女性的激素替代疗法 (HRT) 与手术减少,但抗生素使用更多有关. 这表明HRT可能会改变CRS管理策略.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 慢性鼻炎 (CRS) 显著影响老年妇女的生活质量.
- 激素替代疗法 (HRT) 用于各种更年期症状.
- 了解HRT对CRS管理的影响对于患者护理至关重要.
研究的目的:
- 确定HRT是否会影响绝经后妇女慢性鼻炎 (CRS) 的医疗资源利用.
- 为了比较HRT使用者的手术干预率和抗生素使用率,与使用CRS的非用户相比.
主要方法:
- 使用TrinetX美国健康记录数据库进行回顾性队列研究.
- 纳入55岁以上有CRS的女性,随访3年.
- 对HRT使用者和非使用者的匹配比较,分析内镜外科手术 (ESS) 和抗生素处方.
主要成果:
- HRT的使用与内镜鼻手术 (ESS) 率的显著下降有关 (OR:0.28).
- 在HRT使用者中,ESS的减少更为明显,这些人患有鼻.
- 与非使用者相比,HRT使用者的抗生素处方平均数量较高.
结论:
- HRT与慢性鼻炎 (CRS) 的手术干预 (ESS) 减少有关.
- HRT对减少ESS的影响在患有鼻息肉 (CRSwNP) 的患者中更大.
- 在CRS的管理中,HRT使用与抗生素利用率的增加相关.
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