在阻塞性睡眠呼吸暂停时的喉过敏
Jacquelyn K Callander1, Nazineen Kandahari1, Madeleine P Strohl2
1Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California, U.S.A.
The Laryngoscope
|March 30, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 与喉感觉的减少有关,由较低的喉附加反射 (LAR) 响应率和更快的LAR延迟率证明. 这些发现表明OSA患者的感官功能受损.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 睡眠医学 睡眠医学
- 神经科学是一个神经科学.
背景情况:
- 喉喉感受受损失是阻塞性睡眠呼吸暂停 (OSA) 的潜在因素.
- 喉附加反射 (LAR) 是喉感官功能的一个关键指标.
研究的目的:
- 评估OSA成年人的喉感官功能.
- 评估OSA患者的喉添加器反射 (LAR) 响应率和时间概况.
主要方法:
- 喉感觉测试对具有和没有OSA的清醒成年人进行.
- 触觉刺激被应用到中间的aryepiglottic或arytenoid使用单丝.
- 视频分析评估了LAR的存在和声 adduction的延迟.
主要成果:
- 与对照组相比,OSA患者的LAR反应率显著降低,对于4-0 (38.3%对86.9%) 和5-0 (27%对63.9%) 刺激.
- 在OSA患者 (123.7毫秒) 中,平均LAR延迟时间比对照组 (156.4毫秒) 短.
- OSA LAR延迟与呼吸暂停-呼吸暂停指数呈正相关,表明与疾病严重程度的联系.
结论:
- 在OSA组中,LAR反应率降低,LAR延迟时间缩短.
- 结果证实了OSA中的喉过敏和改变的感觉运动时间动态.
- 潜在的机制包括受体灵敏度下降,交感声调增加,脑干功能改变.
相关概念视频
Sleep Apnea
149
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
149
Larynx
1.5K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
1.5K
Sleep-Wake Cycles
1.3K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K
Hyperpnea and Hyperventilation
1.1K
Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
1.1K
Other Pulmonary Disorders
837
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
837
Local Anesthetics: Adverse Effects
414
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
414


