Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Motor Unit Stimulation01:20

Motor Unit Stimulation

1.5K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
1.5K
Motor Units01:13

Motor Units

3.9K
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
3.9K
The Neuromuscular Junction01:19

The Neuromuscular Junction

9.6K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
9.6K
Hierarchy of Motor Control01:18

Hierarchy of Motor Control

2.7K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Aberrant Pain Phenotypes Emerge Following Prenatal Hypoxic-Ischemic Injury in a Rabbit Model of Cerebral Palsy.

bioRxiv : the preprint server for biology·2026
Same author

Reverse engineering of motor unit discharge in multiple sclerosis reveals heterogeneity of voluntary motor commands.

medRxiv : the preprint server for health sciences·2026
Same author

A novel machine-learning classification model detects oxidative fiber type transitions in a rabbit model of cerebral palsy.

bioRxiv : the preprint server for biology·2026
Same author

Caffeine enhances soleus motoneuron output and preserves torque during repetitive wide-pulse high-frequency stimulation.

Journal of neurophysiology·2026
Same author

The increase in time to task failure following endurance training is associated with adjustments in motor unit firing properties.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Whole-Mount Optical Clearing of Rabbit Tenuissimus Muscle for Assessment of Muscle Spindle Morphology.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jun 29, 2025

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

9.6K

在典型的人类发育中的内在运动神经元特性.

Ghazaleh Mohammadalinejad1,2,3, Babak Afsharipour1,2,3, Alex Yacyshyn1,2

  • 1Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

The Journal of physiology
|March 30, 2024
PubMed
概括

随着年龄的增长,运动神经元的刺激能力会下降,儿童和青少年的激发率比成年人高. 选择性血清素再吸收抑制剂 (SSRI) 也增加了运动神经元的刺激性,类似于发育变化.

关键词:
发动机单位 发动机单位洋皮的皮肤 洋皮持续的内向电流持续的内向电流血清胺的 血清胺的前的前侧.扭矩稳定性扭矩稳定性

更多相关视频

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo
13:07

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo

Published on: December 5, 2012

14.7K
Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices
10:48

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Published on: September 7, 2021

4.7K

相关实验视频

Last Updated: Jun 29, 2025

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation
09:10

The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation

Published on: October 13, 2016

9.6K
Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo
13:07

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo

Published on: December 5, 2012

14.7K
Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices
10:48

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Published on: September 7, 2021

4.7K

科学领域:

  • 神经科学是一个神经科学.
  • 发动机控制器的控制器
  • 发展生物学 发展生物学

背景情况:

  • 运动神经元的特性,包括发射模式和刺激性,在发育过程中发生变化,并受到神经调节剂 (如血清素) 的影响.
  • 持续的向内电流 (PICs) 对于运动神经元刺激性和自我持续的发射至关重要.

研究的目的:

  • 为了研究前运动神经元的自我持续发射和兴奋度的与年龄相关的变化.
  • 检查选择性血清素再吸收抑制剂 (SSRI) 对运动神经元刺激性的影响.

主要方法:

  • 电生理学记录用于测量不同年龄组 (7-17,18-28,32-53岁) 的运动神经元发射特性 (ΔF,发射速率,次要范围).
  • 参与者服用SSRI和年龄相匹配的对照进行了比较.
  • 记录了小腿前部运动神经元的肌肉纤维活动.

主要成果:

  • 与年轻成年人和成年人群相比,在年轻发育群 (7-17岁) 中,自我维持的发射 (ΔF) 显著高于年轻成年人和成年人群,这表明PIC介导的发射在发育过程中下降.
  • 服用SSRI的参与者表现出高于他们年龄相匹配的对照者的 ΔF,这表明脊髓中增加的血清素有助于运动神经元PICs.
  • 青年发育和SSRI组都显示出更高的发射率和更的二次范围,与PIC介导的去极化相一致.
  • 年轻的发育组在背部屈曲扭矩形状上也表现出更大的不稳定性.

结论:

  • 人类运动神经元刺激能力受到PIC的影响,从童年到成年期都会下降.
  • 兴奋剂增加了运动神经元刺激能力,模仿了一些发育变化.
  • 这些发现凸显了运动神经元刺激性及其通过发育和神经化学物质调节的动态性质.