在典型的人类发育中的内在运动神经元特性
Ghazaleh Mohammadalinejad1,2,3, Babak Afsharipour1,2,3, Alex Yacyshyn1,2
1Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
The Journal of physiology
|March 30, 2024
概括
随着年龄的增长,运动神经元的刺激能力会下降,儿童和青少年的激发率比成年人高. 选择性血清素再吸收抑制剂 (SSRI) 也增加了运动神经元的刺激性,类似于发育变化.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 发展生物学 发展生物学
背景情况:
- 运动神经元的特性,包括发射模式和刺激性,在发育过程中发生变化,并受到神经调节剂 (如血清素) 的影响.
- 持续的向内电流 (PICs) 对于运动神经元刺激性和自我持续的发射至关重要.
研究的目的:
- 为了研究前运动神经元的自我持续发射和兴奋度的与年龄相关的变化.
- 检查选择性血清素再吸收抑制剂 (SSRI) 对运动神经元刺激性的影响.
主要方法:
- 电生理学记录用于测量不同年龄组 (7-17,18-28,32-53岁) 的运动神经元发射特性 (ΔF,发射速率,次要范围).
- 参与者服用SSRI和年龄相匹配的对照进行了比较.
- 记录了小腿前部运动神经元的肌肉纤维活动.
主要成果:
- 与年轻成年人和成年人群相比,在年轻发育群 (7-17岁) 中,自我维持的发射 (ΔF) 显著高于年轻成年人和成年人群,这表明PIC介导的发射在发育过程中下降.
- 服用SSRI的参与者表现出高于他们年龄相匹配的对照者的 ΔF,这表明脊髓中增加的血清素有助于运动神经元PICs.
- 青年发育和SSRI组都显示出更高的发射率和更的二次范围,与PIC介导的去极化相一致.
- 年轻的发育组在背部屈曲扭矩形状上也表现出更大的不稳定性.
结论:
- 人类运动神经元刺激能力受到PIC的影响,从童年到成年期都会下降.
- 兴奋剂增加了运动神经元刺激能力,模仿了一些发育变化.
- 这些发现凸显了运动神经元刺激性及其通过发育和神经化学物质调节的动态性质.
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