蛋白质摄入量与重症儿童肌肉衰竭之间的关联:一项前性队列研究
Lyvonne N Tume1,2, Christopher Simons2, Lynne Latten2,3
1Faculty of Health, Special Care & Medicine, Edge Hill University, Ormskirk, UK.
JPEN. Journal of parenteral and enteral nutrition
|March 30, 2024
概括
儿科重症幸存者经历肌肉质量浪费. 这项研究发现,早期蛋白质或能量摄入量与儿童在重症监护期间四头肌肌损失之间没有联系.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 重症监护室 (ICU) 的结果.
- 在危急疾病中提供营养支持.
背景情况:
- 优化儿童重症幸存者的康复是至关重要的.
- 肌肉质量损失是严重疾病期间的一个重要问题.
- 识别影响肌肉消耗的因素对于改善患者的治疗结果很重要.
研究的目的:
- 为了研究四头肌肌肉质量损失和儿科重症中蛋白质/能量摄入之间的关系.
- 用超声波测量来评估肌肉消耗.
- 探索影响危急疾病期间和之后肌肉质量减少的因素.
主要方法:
- 在英格兰的混合心脏和一般儿科重症监护病房进行的前性队列研究.
- 在第1,3,5,7和第10天进行了四头肌肌肉厚度的连续超声波测量.
- 分析包括34名儿童,平均年龄为6.65个月.
主要成果:
- 所有34名儿童都经历了四头肌肌肉衰竭,在重症监护入院期间平均为7.75%.
- 肌肉质量损失与入院后72小时内蛋白质或能量摄入量没有显著关联.
- 没有发现与疾病严重程度,C-反应蛋白水平或类固醇使用的显著相关性. 神经肌肉阻断药物暴露显示了增加肌肉损耗的非显著趋势.
结论:
- 早期的蛋白质和能量摄入 (72小时后) 与儿科重症幸存者的四头肌肉质量损失无关.
- 可能需要进一步的研究来确定有效的干预措施,以减轻这一群体的肌肉损失.
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