产前酒精暴露对围产期结果的剂量反应效应
Ludmila N Bakhireva1, Xingya Ma1, Alexandria Wiesel1
1College of Pharmacy Substance Use Research and Education Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Alcohol, clinical & experimental research
|March 30, 2024
概括
产前酒精暴露 (PAE),即使在轻度至中度水平或偶尔饮酒时,也会对妊娠年龄和出生时间产生负面影响. 这些发现强调了在生育年龄的妇女中早期预防PAE的必要性.
科学领域:
- 产科和妇科 产科和妇科
- 胎儿的发育 胎儿的发育
- 公共卫生 公共卫生
背景情况:
- 产前酒精暴露 (PAE) 是常见的,但较低水平的影响需要进一步了解.
- 轻度中度的PAE和偶尔的狂饮是普遍存在的,需要对其围产期影响进行调查.
研究的目的:
- 检查轻度至中度PAE和偶尔暴饮暴饮对围产期结局的影响.
- 调查各种酒精消费指标与妊娠年龄和人类测量结果之间的关联.
主要方法:
- 一项前性队列研究,共有281名参与者 (125名有PAE,156名没有).
- 通过AUDIT,时间线追踪和生物标志物评估的酒精消耗,估计每天绝对酒精 (AAD),每天饮酒 (AADD),狂饮情节和最大饮料.
- 围产期结局包括妊娠年龄和人类测量;数据分析使用相关性和多变量回归.
主要成果:
- 轻度中度的PAE与降低分娩时的妊娠年龄有关,即使考虑到妊娠前期.
- 较高的酒精摄入量 (AAD,AADD) 显示,经过对混因素进行调整后,与妊娠年龄有显著的负面关联.
- 在24小时内最大饮料与较低的出生长度百分位数显著相关;在单变量分析中,PAE与较低的出生体重百分位数相关.
结论:
- 轻度中度的PAE和偶尔的暴饮暴酒与分娩时的妊娠年龄和出生长度百分比负相关.
- PAE,包括在孕期期间,对妊娠持续时间有显著的负面影响.
- 在生育年龄的妇女中,对PAE的初级预防至关重要.
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