德克萨斯州非小细胞肺癌免疫疗法利用模式在监管批准前和后
Olajumoke Adenike Olateju1, Zhen Zeng1, Marjan Zakeri1
1Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Health 2, Room 4050, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5047, USA.
概括
社会经济地位对德克萨斯州非小细胞肺癌 (NSCLC) 的免疫疗法使用有重大影响. 需要进行改革,以解决差异,并改善获得这种重要癌症治疗的机会.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 免疫疗法已经彻底改变了非小细胞肺癌 (NSCLC) 治疗,提供了显著的好处.
- 与全国平均水平相比,德克萨斯州在提供公平获得NSCLC治疗方面面临挑战.
研究的目的:
- 在美国FDA批准之前和之后,评估德克萨斯州的第一线免疫疗法治疗模式.
- 确定与德克萨斯州NSCLC患者免疫疗法利用相关的因素.
主要方法:
- 使用德克萨斯州癌症登记数据库 (2011-2018) 的回顾性队列研究.
- 免疫疗法利用率和趋势的分析 (年平均百分比变化) 在FDA批准之前和之后.
- 多变量逻辑回归用于评估与转移性和所有阶段NSCLC免疫疗法使用相关的患者特征.
主要成果:
- 德克萨斯州的免疫疗法利用率在FDA批准后增加 (1.7%至13.0%),年平均百分比变化更高.
- 预先批准,较低的家庭收入和私人保险与免疫疗法使用有关.
- 在批准后,社会经济差异,特别是与贫困水平相关的差异,在转移性NSCLC患者中变得更加明显并持续存在.
结论:
- 患者的社会经济地位是德克萨斯州NSCLC免疫疗法利用的重要障碍.
- 调查结果强调需要国家级卫生政策改革,包括医疗补助扩展和向癌症治疗策略,以减轻这些差异.
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