相关实验视频
Updated: Jul 12, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
12.4K
在顶级皮肤病学期刊中与状细胞癌相关的随机对照试验中的皮肤颜色报告:系统性审查
Natasha L Salmen1, Klarens Menage2, Anthony N Baumann2
1Northeast Ohio Medical University, Rootstown, OH, United States. nsalmen@neomed.edu.
Archives of dermatological research
|March 30, 2024
概括
皮肤颜色数据在状细胞癌 (SCC) 临床试验中报告不足. 在顶级期刊上的研究中,只有不到60%的研究包括了这一关键的人口信息,阻碍了公平的癌症护理.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 临床研究方法论 临床研究方法论
背景情况:
- 皮肤癌,特别是状细胞癌 (SCC),不成比例地影响个人基于皮肤颜色.
- 准确的人口统计数据,包括皮肤颜色,对于了解疾病表现,治疗疗效和不同人群的结果至关重要.
- 以前的研究表明,皮肤病学研究报告中的患者人口统计数据可能存在差异.
研究的目的:
- 量化皮肤颜色在随机对照试验 (RCT) 中报告的频率,用于状细胞癌 (SCC) 检测和治疗.
- 在领先的皮肤病学期刊中识别皮肤颜色报告的趋势.
- 评估研究特征 (地点,出版年份,资金) 对皮肤颜色数据纳入的影响.
主要方法:
- 从开始到2023年7月10日,在十大皮肤病学期刊上发表的涉及SCC的RCT的系统审查.
- 纳入标准:以SCC治疗,预防或检测为重点的RCT,涉及患者直接参与.
- 皮肤颜色报告被定义为在研究方法或结果中存在诸如菲茨帕特里克尺度,种族,种族,晒伤倾向或皮肤颜色等术语.
主要成果:
- 在39个已识别的SCCRCT中,23个 (59.0%) 报告了与皮肤颜色相关的数据.
- 白人是报告频率最高的人口群体 (56.5%).
- 小组分析显示,根据研究地点,出版年或资金来源,报告率在统计学上没有显著差异;报告在过去二十年中没有得到改善.
结论:
- 在领先的皮肤病学期刊中,很大一部分高质量的SCCRCT未能报告皮肤颜色的人口统计数据.
- 皮肤颜色数据的持续报告不足可能会掩盖SCC呈现,治疗反应和人群中复发的关键差异.
- 需要进一步调查,以解决低报告率及其对公平皮肤癌症护理的社会影响.
更多相关视频
06:11Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
9.8K
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
相关概念视频
01:19Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...