隐性肺癌与自身免疫性脑炎相关,呈现为急性精神病
Shelly K McCarter1, K Robert Shen2, Mark E Wylam3
1Department of Surgical Services, Naval Hospital Pensacola, Pensacola, FL 32412, USA.
Military medicine
|March 30, 2024
概括
一名士兵经历了急性行为变化,被诊断为由抗N-甲基-D-酸盐受体抗体引起的自身免疫性脑炎. 治疗包括免疫疗法和手术导致显著改善.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 急性行为变化可以模仿精神疾病.
- 自身免疫性脑炎是神经和精神症状的新兴原因.
研究的目的:
- 报告一种抗N-甲基-D-酸盐受体脑炎病例,呈现急性行为变化.
- 为了突出自身免疫性脑炎和恶性瘤之间的关联.
主要方法:
- 临床评估包括神经学检查和神经成像 (MRI).
- 脑脊液 (CSF) 对自身抗体的分析.
- 对潜在恶性瘤的诊断工作.
主要成果:
- 患者出现了急性脑病变和行为变化.
- 核磁共振扫描显示了T2强度过高.
- 对抗N-甲基-D-酸盐受体抗体的CSF阳性.
- 丸中的核蛋白在肺部发现的瘤.
结论:
- 与抗N-甲基-D-酸盐受体抗体相关的自身免疫脑炎可以表现为急性行为变化.
- 早期诊断和治疗,包括免疫疗法和瘤切除,对于恢复至关重要.
- 这一案例强调了在患有无法解释的急性行为变化的患者中考虑自身免疫脑炎的重要性,特别是当与恶性瘤相关时.
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