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在患有差异化甲状腺癌的患者中,Panax Ginseng对131I诱导的基因毒性的保护作用

Vida Omrani¹, Reza Fardid^1,2, Mehrosadat Alavi^2,3,4

¹Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Journal of cancer research and therapeutics

|March 30, 2024

概括

帕纳克斯人参 (PG) 补充剂在差异化甲状腺癌患者中显著降低了放射性治疗诱导的DNA损伤. 这项研究表明PG作为RAIT的基因毒性防护剂.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
药理学药理学是指药理学的学科.

背景情况:

针对差异化甲状腺癌 (DTC) 的放射性治疗 (131I) 可以导致氧化应激和DNA损伤.
对RAIT诱导的基因毒性进行保护剂的评估对于患者护理至关重要.

研究的目的:

评估Panax人参 (PG) 在缓解DTC患者131I治疗引起的基因毒性方面的疗效.
研究PG对DNA损伤标志物和氧化应激指标的影响.

主要方法:

接受131I治疗的40名DTC患者被分为对照组,安慰剂组和两个PG治疗组.
测量了淋巴细胞微核 (MN) 频率,血清总抗氧化能力 (TAC) 和缺血变异性白蛋白 (IMA).
肝脏和脏功能的生物标志物也被监测.

主要成果:

与基线相比,RAIT显著增加了对照组和安慰剂组的MN频率.
在治疗组中,PG的使用显著降低了RAIT诱导的MN频率 (P < 0.001).
PG并没有显著改变IMA,TAC或肝/毒性标志物.

结论:

在DTC患者中,帕纳克斯人参显示出对放射性治疗诱导的染色体损伤的保护作用.
PG可以作为有益的辅助疗法,以减少RAIT的基因毒性副作用.

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