在晚期口腔癌中吞:一项前性观察性研究
Akshat Malik1, Florida Sharin1, Arun Balaji2
1Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
Journal of cancer research and therapeutics
|March 30, 2024
概括
先进的口腔癌治疗在治疗结束后很长一段时间内显著损害了吞功能. 早期干预和康复对于在癌症幸存者中管理这种持续性消化障碍至关重要.
科学领域:
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 语音语言病理学 语音语言病理学
背景情况:
- 晚期头癌经常导致吞功能障碍,原因是解剖学和治疗相关的变化.
- 有限的研究存在于手术后的吞功能和高级口腔癌的多模式治疗.
- 这项研究通过纵向评估局部晚期口腔癌的吞功能障碍来弥补这一差距.
研究的目的:
- 纵向评估和比较治疗前和治疗后的吞功能障碍.
- 评估手术和辅助治疗对晚期口腔癌患者吞功能的影响.
主要方法:
- 在第三级癌症中心 (2017-2018) 进行前性纵向观察性研究.
- 包括未接受过治疗的cT4a口腔癌患者 (AJCC第7版).
- 吞功能评估了手术前,手术后和辅助疗法后的吞功能,使用失消症得分,透吸收量表 (PAS) 和耶鲁喉残留量表.
主要成果:
- 在术后,47.4%-52.6%的患者表现出吞功能得分的恶化 (吞障碍,PAS,残留物).
- 在辅助治疗6个月后,47.4%-68.4%的患者仍然表现出吞功能受损.
- 消化不良得分与其他客观的吞评估措施有很好的相关性.
结论:
- 手术和辅助疗法显著影响吞功能,治疗后至少持续六个月的缺陷.
- 早期和适当的康复干预对于缓解长期吞问题至关重要.
- 消化不良分数作为吞状态的可靠预测指标,与客观评估相提并论.
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