年龄较小的上皮卵巢癌与年龄较大的卵巢癌:生存率和临床病理特征
Walaiporn Kongkamsuan1, Sathana Boonyapipat
1Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla.
Journal of cancer research and therapeutics
|March 30, 2024
概括
年轻的上皮卵巢癌 (EOC) 患者的无进展生存率 (PFS) 较好,但与老年患者相比,疾病特异性生存率 (DSS) 类似. 年龄较小是早期预后不佳的因素,但在三年后变得有利.
科学领域:
- 妇科瘤学 妇科瘤学
- 临床癌症研究 临床癌症研究
- 流行病学 流行病学
背景情况:
- 表皮卵巢癌 (EOC) 的存活率和特征可以随患者年龄而有显著差异.
- 了解与年龄相关的差异对于优化EOC的治疗和预后评估至关重要.
研究的目的:
- 为了比较40岁以下的患者的生存结果和EOC的临床病理特征,与40岁以上的患者相比.
- 为了确定年龄较小对EOC预后随着时间的推移的影响.
主要方法:
- 匹配的队列研究比较了763名EOC患者 (≤40岁与>40岁) 在1:4的比率.
- 对疾病特异性生存率 (DSS),无进展生存率 (PFS) 和临床病理特征的分析.
- 两个年龄组之间的结果的统计比较.
主要成果:
- 年轻和年长的EOC患者 (120岁与84.7个月) 之间的DSS中位数没有显著差异.
- 年轻患者的PFS中位数显著改善 (未达到vs. 41个月).
- 年轻患者的早期疾病,粘膜亚型和较低的CA-125水平的发病率更高.
结论:
- 年轻的EOC患者与老年同行相比,表现出更有利的预后因素和改善的PFS,但没有DSS.
- 年龄较小是诊断后3年内不良预后因素,随后转变为有利因素.
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