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氨酸验证的吸烟状态与胆结石风险之间的关联:一项队列研究
Nam Hee Kim1, Ji Hun Kang2, Hong Joo Kim1
1Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Journal of gastrointestinal and liver diseases : JGLD
|March 30, 2024
概括
吸烟是胆结石的重要危险因素之一. 这项研究使用尿路丁氨酸客观地验证吸烟状态,证实自我报告和验证的吸烟都会增加胆结石风险.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 以前关于吸烟和胆结石的研究是相互矛盾的,通常依赖于自我报告的数据.
- 像尿路中的科提宁这样的客观生物标志物提供了更可靠的烟草暴露量.
研究的目的:
- 通过自我报告的数据和客观的尿中丁氨酸水平,研究吸烟和胆结石发展之间的关联.
- 澄清烟草吸烟作为胆结石风险因素的作用.
主要方法:
- 对221,721个无症状的成年人进行了分析,这些成年人接受了腹部超声波和尿路丁胺测量.
- 丁素验证的当前吸烟者的定义是尿中丁素水平≥50 ng/mL的个体.
- 以混因素进行统计调整.
主要成果:
- 自我报告和经过丁胺验证的当前吸烟都与胆结石发病风险增加有关.
- 胆结石的风险增加了更高的包年吸烟史.
- 在自我报告的非吸烟者中,用氨酸验证的吸烟者患胆结石的风险明显更高.
结论:
- 烟草吸烟,客观地通过尿液中丁氨酸验证,是胆结石的独立风险因素.
- 烟草吸烟在胆结石的发展中起着独特的作用.
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