流产和死产与心血管疾病风险有关:系统性审查和元分析
Mengmeng Wang1, Jinli Zhang1, Lijun Yuan1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
概括
失去怀孕,包括流产和死胎,与心血管疾病 (CVD) 的风险增加有关. 心血管疾病和冠心病的风险随着每次额外的怀孕流产事件而增加.
科学领域:
- 心血管健康 心血管健康
- 生殖医学 生殖医学
- 流行病学 流行病学
背景情况:
- 流产 (流产,死胎) 和心血管疾病 (CVD) 风险之间的关联尚未完全确定.
- 以前的研究对这种关系提出了相互矛盾的发现.
研究的目的:
- 进行一项元分析,调查流产和死产之间的联系以及随后患心血管疾病的风险.
- 为了量化怀孕流产后各种心血管结果的风险.
主要方法:
- 在PubMed,Embase和Web of Science数据库中进行系统的文献搜索,直到2023年5月.
- 使用随机效应模型计算聚合相对风险 (RRs) 和95%置信区间 (CI) 的元分析.
- 一般化最小平方回归用于评估每次新增流产或死产的风险变化.
主要成果:
- 包括23项研究. 流产史与全心血管疾病 (RR 1.16),冠心病 (CHD) (RR 1.26),中风 (RR 1.13) 和心血管疾病死亡 (RR 1.20) 的风险增加有关.
- 死亡出生史显示,总心血管疾病 (RR 1.60),心血管疾病 (RR 1.30),中风 (RR 1.37) 和心血管疾病死亡 (RR 1.95) 的风险更高.
- 每次额外流产都会增加心血管疾病风险 (心血管疾病总RR1.08,心血管疾病RR1.08,中风RR1.05). 每个额外的死产都会增加心血管疾病的总风险 (RR 1.11) 和心血管疾病的风险 (RR 1.13).
结论:
- 流产和死胎都与总心血管疾病,心血管疾病,中风和心血管疾病死亡率的风险增加有关.
- 心血管疾病和冠心病的风险随着流产或死产数量的增加而升级.
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