在主要抑郁症中,在情绪调节期间减少了前结节连接性
Saskia Steinmann1, Kim Janine Tiedemann1, Stephanie Kellner1
1Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Journal of psychiatric research
|March 30, 2024
概括
大型抑郁症 (MDD) 患者在认知重新评估过程中表现出额头塔活性和连接性降低. 这种功能障碍可能解释了MDD情绪调节的困难和较差的心理健康.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 认知重新评估是关键的情绪调节技能,对社会和心理健康至关重要.
- 患有严重抑郁症 (MDD) 的人表现出受损的认知重新评估能力.
- 在成功的认知重新评估过程中,健康对照组 (HC) 在前额和皮下网络中表现出theta活动.
研究的目的:
- 与HC相比,在MDD患者的认知再评估期间调查theta功率和连接性的变化.
- 探索MDD和HC中theta连接和自我报告的情绪调节策略之间的关系.
主要方法:
- 使用了脑电图 (EEG) 和标准化低分辨率电磁断层扫描 (eLORETA).
- 25名HC和24名MDD患者执行了涉及中性和负面图像的情感认知重新评估任务.
- 认知情绪调节问卷 (CERQ) 评估了习惯性情绪调节技能.
主要成果:
- 患有MDD的患者在左背侧前额叶皮层 (dlPFC),后中侧前额叶皮层 (dmPFC) 和面腹侧环状皮层 (rvACC) 中表现出降低的甲基活性.
- 在重新评估期间,与HC相比,在MDD患者中观察到dlPFC-rvACC甲基连接的减少.
- 在HC中,左 dlPFC-rvACC 甲基连接与认知重新评估相关,MDD中没有这种相关性. 患有MDD的患者报告了更高的使用不足和较低的使用适应性情绪调节技能.
结论:
- 研究结果表明,在MDD中存在前结状功能障碍,这可能是情绪调节障碍的潜在原因.
- 这种功能障碍可能导致不适应性策略的使用增加和适应性情绪调节技能的使用减少.
- 改变的甲基活动和连接性代表了MDD情绪调节缺陷的潜在神经标志物.
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