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在NMOSD和MOGAD中脑脊髓缩:当前的证据和未来的前景

L Lorefice¹, R Cortese²

¹Department of Medical Sciences and Public Health, Multiple Sclerosis Center, Binaghi Hospital, ASL Cagliari, University of Cagliari, Via Is Guadazzonis 2, Cagliari 09126, Italy.

Multiple sclerosis and related disorders

|March 30, 2024

概括

神经脊髓炎光学谱系障碍 (NMOSD) 和MOGAD涉及中枢神经系统的炎症. 研究表明,在这些情况下,慢性大脑和脊髓缩,指导个性化治疗超出急性阶段.

科学领域:

神经免疫学神经免疫学
神经学神经学
中枢神经系统 (CNS) 疾病

背景情况:

神经脊髓炎光学谱系障碍 (NMOSD) 是一种中枢神经系统炎症状况,按抗aquaporin-4抗体 (AQP4) 状态分类.
髓寡细胞糖蛋白抗体相关疾病 (MOGAD) 是一个诊断挑战,患者显示NMOSD表型,但测试MOGAD阳性.
无论是NMOSD还是MOGAD,都主要是复发性炎症性中枢神经系统疾病,尽管MOGAD也可以是单相性.

研究的目的:

审查当前关于成人NMOSD和MOGAD中大脑和脊髓测量的文献.
探索这些测量和临床表现之间的关系.
区分这些疾病与多发性硬化症 (MS) 并确定未来的研究方向.

主要方法:

在NMOSD和MOGAD中调查大脑和脊髓缩的研究的系统综述.
分析中枢神经系统测量的纵向变化.
发现与临床数据和多发性硬化症 (MS) 病理学的比较.

主要成果:

证据表明,在NMOSD和MOGAD中,亚临床病理过程导致慢性大脑和脊髓缩.
纵向研究显示,即使在急性炎症阶段之外,组织也会逐渐受损.
在NMOSD,MOGAD和MS之间可能存在明显的缩模式.

结论:

慢性损伤过程,由大脑和脊髓缩表示,存在于NMOSD和MOGAD.
了解这些慢性变化对于定制治疗干预至关重要.
需要进一步的研究来完善这些独特的神经炎症疾病的诊断标准和治疗策略.

关键词:

抗水素-4 抗体的抗体大脑体积的大脑体积深灰色物质是一种深灰色物质.骨髓寡腺细胞葡萄糖蛋白抗体神经脊髓炎光学谱系疾病脊髓缩脊髓缩脊髓缩脊髓缩

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