评估缓冲与非缓冲利多卡因在牙提取中的有效性:双盲随机对照试验
Yotom Rabinowitz1, Skyler Williams2, Reese R Triana3
1Assistant Professor, Department of Surgery, Virginia Commonwealth University Health System, Richmond, VA.
概括
与标准利多卡因相比,缓冲利多卡因注射在减少疼痛或在牙科手术期间更快开始方面没有显著的益处. 需要进一步的研究来证实口服麻醉的有效性.
科学领域:
- 口腔和牙面部外科手术
- 麻醉学 麻醉学
- 牙科研究 牙科研究
背景情况:
- 缓冲利多卡因注射理论上是为了减少不适和提高麻醉疗效.
- 之前对缓冲利多卡因在口服麻醉中的研究已经产生了不确定的结果.
研究的目的:
- 为了评估二碳酸缓冲2%的利多卡因是否与非缓冲利多卡因相比,可以减少注射疼痛.
- 为了确定缓冲利多卡因是否能在牙科麻醉中提供更快的起作用和更高的疗效.
- 为了评估充足麻醉所需的注射轮数量,使用缓冲式与非缓冲式利多卡因.
主要方法:
- 一个单中心,双盲,随机对照试验在口腔和面外科诊所进行.
- 需要一次牙拔牙的参与者被随机分配给接受非缓冲或碳酸缓冲的2%利多卡因与上腺素.
- 主要结局包括注射疼痛得分,术后疼痛,麻醉开始时间和所需注射次数.
主要成果:
- 缓冲利多卡因在注射疼痛,术后疼痛或发病时间方面没有显示出统计学上显著的改善.
- 诸如关 involvement,患者年龄和手术前疼痛等因素与注射疼痛和所需麻醉剂轮次数有显著联系.
- 对于任何主要结果,在缓冲和非缓冲利多卡因之间没有发现统计学上显著的差异.
结论:
- 在这个研究群体中,2%的利多卡因的二碳酸缓冲没有在非缓冲利多卡因上提供明显的优势.
- 这些发现表明,缓冲利多卡因可能不会在牙提取的情况下提供更好的疼痛缓解或更快的开始.
- 关于局部麻醉的临床决策应考虑患者特异性因素和既定的麻醉方案.
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