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Updated: May 3, 2026

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在前额前塞塔突发刺激期间的神经反应:跨叶TMS-fMRI全 iTBS 协议的交叉TMS-fMRI

Kai-Yen Chang¹, Martin Tik², Yuki Mizutani-Tiebel¹

¹Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; Neuroimaging Core Unit Munich - NICUM, University Hospital, LMU Munich, Munich, Germany.

|March 30, 2024

概括

这项研究表明,将跨磁刺激 (TMS) 与功能性MRI (fMRI) 结合起来,可以观察抑郁症中间歇性甲基突发刺激 (iTBS) 期间的大脑变化. 这种方法有助于理解iTBS如何影响大脑网络.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
精神病学是一个精神病学.

背景情况:

间歇性甲爆刺激 (iTBS) 是一种用于治疗抑郁症的TMS协议.
了解iTBS的大脑网络效应和目标参与对于机械洞察至关重要.
以前的研究集中在网络效应上,但直接观察即时效应是有限的.

研究的目的:

调查一种新的综合TMS-fMRI设置的可行性,以观察完整的iTBS会话的直接影响.
测试TMS诱导刺激和相互连接的大脑区域急性BOLD信号变化的假设.

主要方法:

同时的TMS-fMRI与神经导航iTBS (600脉冲) 的左背侧前额皮层 (DLPFC) 在18名健康参与者.
在治疗双极性抑郁症的维持性iTBS患者中进行了四次TMS-fMRI疗程.

主要成果:

同时的TMS-fMRI对于完整的iTBS会话是可行的.
交联的iTBS-fMRI在双边DLPFC网络中显示了增加的BOLD信号.
临床案例显示左侧DLPFC和下肢前带带皮层的BOLD反应减少,会话变化.

结论:

完整的iTBS会话与交联的iTBS-fMRI范式兼容.
这种方法可以证明目标参与,并探索iTBS在临床人群中的治疗机制.
未来的研究可以利用这种方法来研究抑郁症患者的iTBS.

关键词:

同时进行的TMS-fMRI.功能性MRI (fMRI) 是一种功能性MRI.交联的iTBS-fMRI可以进行.神经调节是一种神经调节.非侵入性大脑刺激通过的磁性刺激 (TMS)

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