Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.6K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.6K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.8K
Cell Migration01:09

Cell Migration

17.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same author

Bridging the gap: towards a digital twin to optimize therapeutic cell-seeding strategies in nerve tissue engineering.

Journal of the Royal Society, Interface·2026
Same author

Decellularization of porcine small-diameter vascular grafts: evaluation of a latrunculin B-based method and novel perfusion approach.

Biofabrication·2026
Same author

Peptides Targeting GDNF Family Receptor Alpha 1 (GFRα1) Mimic Glial Cell Line-Derived Neurotrophic Factor (GDNF) Bioactivity.

Journal of medicinal chemistry·2026
Same author

Evaluation of a GDNF-eluting nanofibrous PCL conduit in a mouse model of peripheral nerve injury.

RSC advances·2026
Same author

Advanced three-dimensional in vitro models for Parkinson's disease research.

Neural regeneration research·2026

相关实验视频

Updated: Jun 29, 2025

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.5K

使用化疗驱动的多相模型形成血管类结构.

Georgina Al-Badri1, James B Phillips2, Rebecca J Shipley3

  • 1Department of Mathematics, University College London, London, UK; Centre for Nerve Engineering, University College London, London, UK.

Mathematical biosciences
|March 30, 2024
PubMed
概括

这项研究介绍了在细胞外矩阵 (ECM) 中细胞模式的多相模型. 该模型模拟了化疗驱动的细胞迁移,形成血管类结构,并确定体外血管网络形成的关键参数.

关键词:
化学反应的化学作用.多相建模 多相建模组织工程是组织工程.血管生成是一种血管生成.

更多相关视频

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.0K
Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

10.1K

相关实验视频

Last Updated: Jun 29, 2025

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.5K
Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.0K
Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

10.1K

科学领域:

  • 计算生物学 计算生物学
  • 生物物理学的生物物理.
  • 组织工程是组织工程.

背景情况:

  • 细胞模式对于组织发育和功能至关重要.
  • 了解体外细胞组织是组织工程应用的关键.

研究的目的:

  • 开发和验证一个连续性的多相模型,以模拟体外细胞模式.
  • 研究驱动模式形成的机制,包括化疗和细胞矩阵相互作用.
  • 在1D和2D中模拟血管类结构的形成.

主要方法:

  • 使用多相模型框架进行连续细胞模式.
  • 嵌入的化学作用驱动的细胞迁移,细胞矩阵引,接触抑制和细胞-细胞聚合.
  • 进行灵敏度分析以确定关键模型参数.
  • 包括化学吸引剂-矩阵结合,以改进空间尺度.

主要成果:

  • 化学作用驱动的迁移成功地产生了细胞群 (1D) 和血管类结构 (2D).
  • 细胞矩阵引,接触抑制和聚合影响了模式形成.
  • 化学吸引剂-矩阵结合将模式尺度降低到生物学相关的范围.
  • 1D模型的发现有效地转化为2D模拟,产生血管模式.

结论:

  • 开发的多相模型准确地模拟了长期的体外细胞模式形成.
  • 该模型为研究血管网络发展提供了一个生物学上可信的框架.
  • 确定了影响模式形成的关键参数,有助于未来的实验设计.