基于BMI的代谢综合征严重性得分和动脉硬性在一个中国队列研究中
Miao Wang1, Chi Wang2, Maoxiang Zhao2
1The School of Medicine, Nankai University, No.94 Weijin Road, Nankai District, Tianjin 300071, China; Department of Cardiology, Chinese People's Liberation Army General Hospital, No.28 Fuxing Road, Beijing 100853, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|March 30, 2024
概括
更高的代谢综合征严重性z分数 (MetS-Z) 与动脉硬 (AS) 的风险增加有关. 这种关联在没有肥胖,高血压或糖尿病的年轻,健康的个体中尤为明显.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 血管生物学 血管生物学
背景情况:
- 代谢综合征 (MetS) 是一组增加心脏病,中风和糖尿病风险的疾病.
- 动脉硬 (AS) 是血管衰老的标志物和心血管事件的预测因素.
- 需要进一步调查MetS和AS严重程度之间的关系.
研究的目的:
- 调查累积代谢综合征严重程度z分数 (cMetS-Z) 和动脉硬 (AS) 之间的关系.
主要方法:
- 从2006年开始,7621名参与者的队列接受了体检和臂脉冲波速度 (ba-pwv) 测试.
- 累积的MetS-Z是使用血压,甘油三,高密度胆固醇,血糖和BMI来计算的.
- 使用考克斯回归和立方脊柱模型来评估cMetS-Z和AS之间的风险和关系.
主要成果:
- 在平均6.27年的随访期间,发现了1831例AS病例.
- 随着cMetS-Z.高四分位数的增加,AS的发病率逐渐增加.
- 与最低四分之一相比,AS的调整后危险比率从cMetS-Z的第二到第四个四分之一显著增加.
结论:
- 升高的cMetS-Z显著与患动脉硬度的风险增加有关.
- 这种关联在没有肥胖,高血压或糖尿病的个体中更为明显,这表明在心血管风险的早期阶段可能发挥作用.
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