多发性骨髓瘤延迟诊断的患病率和后果:一个单一机构的经验
Paola Negrete-Rodríguez1, Moisés Manuel Gallardo-Pérez2, Olivia Lira-Lara3
1Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México; Facultad de Medicina, Universidad de las Américas Puebla, Puebla, México.
Clinical lymphoma, myeloma & leukemia
|March 30, 2024
概括
多发性骨髓瘤 (MM) 的延迟诊断在墨西哥很常见,影响68%的患者. 然而,这项研究没有发现延迟的MM诊断和较差的生存结果之间的显著联系.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 多发性骨髓瘤 (MM) 经常表现出非特异性症状,可能延迟诊断.
- 延迟诊断可能与并发症增加和整体存活率 (OS) 降低有关.
研究的目的:
- 调查延迟多发性骨髓瘤诊断对OS和无进展生存时间 (PFS) 的影响.
- 分析墨西哥患者队列中的诊断延迟.
主要方法:
- 对136名在1983年至2022年期间被诊断为多发性髓瘤患者的回顾性分析.
- 根据诊断延迟 (症状发作到诊断) 患者被分为四组:<3个月,3-6个月,6-12个月和>12个月.
主要成果:
- 在68%的患者中观察到诊断延迟 (>3个月).
- 在3个月内或之后诊断的患者之间,没有发现OS或PFS的显著差异.
- 6-12个月的诊断延迟组显示出最好的中位数OS和DFS.
结论:
- 在墨西哥,多发性骨髓瘤的延迟诊断非常普遍.
- 尽管出现了早期诊断的趋势,但诊断延迟和不良预后之间没有直接的相关性.
- 需要进一步的研究来探索这些发现的潜在解释.
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