跨主要精神疾病的遗传和表型相似性:系统性审查和定量评估
Vincent-Raphael Bourque1, Cécile Poulain1, Catherine Proulx1
1CHU Sainte-Justine Azrieli Research Center, Université de Montréal, Montreal, QC, Canada.
Translational psychiatry
|March 30, 2024
概括
精神疾病具有共同的遗传和大脑相似性,这解释了它们的大部分重叠. 然而,这些生物学共同点并不能完全解释观察到的临床症状相似性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 主要的精神疾病在遗传,神经和症状层面上具有显著的重叠.
- 这些共同点在不同观察水平之间相对应的程度尚不清楚.
研究的目的:
- 系统地审查和比较主要精神疾病之间的相似程度在所有可用的观察水平.
- 为了研究基因和神经相似性对临床症状重叠的映射.
主要方法:
- 在PubMed和EMBASE (2009-2022) 的系统文献搜索中,对比至少四种疾病的研究 (精神分裂症,双极性障碍,严重抑郁症,自闭症谱系障碍,注意力缺陷多动性障碍).
- 根据PRISMA指南进行数据提取和合成,重点关注跨基因 (SNP,基因基因,基因表达) 和神经成像 (结构/功能连接) 层面的相似度 (皮尔森相关性).
- 主要组件分析以确定共识障碍相似度排名.
主要成果:
- 28项研究符合条件,分析了遗传和神经成像数据.
- 大多数相关性 (88.6%) 跨疾病和观察水平是积极的,表明广泛的相似性.
- 第一个主要组成部分解释了51.4%的疾病相似性差异,这表明了统一因素.
结论:
- 遗传和大脑因素对精神疾病中观察到的重叠有显著的贡献.
- 虽然生物学上的共同点很大,但它们并不能完全解释精神病诊断中出现的临床症状重叠的全谱.
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