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Updated: Jun 24, 2026

Facial Nerve Axotomy in Mice: A Model to Study Motoneuron Response to Injury
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神经毒剂VX对来自hiPSC的运动神经元的影响

Catherine Schaefers1, Wolfgang Schmeißer2, Harald John2

  • 1Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstr. 11, 80937, Munich, Germany. catherine.schaefers@t-online.de.

Archives of toxicology
|March 30, 2024
PubMed
概括

有机神经毒剂VX中毒会导致神经元细胞死亡,并减少人体干细胞衍生的运动神经元中神经元外生. 这项研究建立了一个用于研究VX毒性和开发新疗法的人类模型.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.在BCL2A1A1中.在CASP10中,CASP10是这是神经毒剂.神经毒性 神经毒性qRT-PCR 是一个很好的方法.

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...