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Updated: Jun 29, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
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抑制CDC7驱动着炎症反应和乳腺上皮细胞中的p53依赖的衰老状态

Chiara Cazzaniga1, Anja Göder1, Michael David Rainey1

  • 1Centre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland.

The FEBS journal
|March 31, 2024
PubMed
概括

抑制乳腺细胞中的细胞分裂周期7相关蛋白激酶 (CDC7) 会导致可逆衰老状态. 这种反应取决于细胞瘤抗原p53 (p53) 的功能,影响潜在的抗癌药物开发.

关键词:
复制DNA复制DNA复制DNA复制这是一种炎症炎症炎症炎症.激酶抑制剂 激酶抑制剂衰老是一种老化.

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