高压氧气疗法对口腔候群病糖尿病的功效
Kristanti Parisihni1, Dian Mulawarmanti1, Kharinna Widowati2
1Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah, Surabaya, Indonesia.
European journal of dentistry
|March 31, 2024
概括
高压氧疗法 (HBOT) 通过降低血糖和增加淋巴细胞,有效地管理糖尿病大鼠的口腔候群病. 结合的HBOT和尼斯塔丁在减少抗坎迪达抗体方面显示出最好的结果.
科学领域:
- 生物医学研究的研究.
- 口服药是一种口服药.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病复杂化了口腔健康,增加了对口腔疹等感染的易感性.
- 在糖尿病患者中治疗口腔候群症需要解决血糖控制和真菌感染.
研究的目的:
- 评估高压氧疗法 (HBOT) 在糖尿病大鼠模型中治疗口腔候群病的疗效.
- 评估HBOT对血糖水平,淋巴细胞计数和抗坎迪达抗体表达的影响.
主要方法:
- 三十只Wistar老鼠被诱导患有糖尿病和口腔候群病.
- 治疗组包括nystatin,HBOT (2.4 ATA) 和nystatin和HBOT的组合,以及对照组.
- 在治疗5天后,分析了血糖,淋巴细胞计数和抗坎迪达抗体表达.
主要成果:
- HBOT显著增加了淋巴细胞计数 (p < 0.05),并显示了降低血糖水平的趋势 (p > 0.05).
- 所有治疗,包括HBOT和nystatin,降低了抗坎迪达抗体表达 (p <0.05).
- 结合HBOT和尼斯塔丁,产生了最显著的降低抗坎迪达抗体.
结论:
- 高压氧气疗法在糖尿病患者的口腔候群病管理方面显示出潜在的潜力.
- HBOT积极影响关键标记物,如血糖和淋巴细胞水平.
- 与尼斯塔丁的联合治疗在糖尿病口服候群病中提供了增强的疗效.
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