在ELSA-巴西研究中,分支链氨基酸与功能之间的关联
Viviane Calice-Silva1, Isabela M Bensenor2, Silvia M Titan2
1Pro-rim Foundation, Joinville, Brazil; School of Medicine, UNIVILLE, Joinville, Brazil; Center for Clinical and Epidemiologic Research, Hospital Universitario, University of São Paulo, Sao Paulo, Brazil.
Clinical nutrition (Edinburgh, Scotland)
|March 31, 2024
概括
高循环的分支链氨基酸 (BCAA) 与估计的膜过率 (eGFR) 呈现反向关联,与专蛋白-肌素比率 (ACR) 呈现积极关联. 需要进一步的研究来了解这些功能联系.
科学领域:
- 代谢健康 代谢健康
- 脏生理学 脏生理学
- 流行病学 流行病学
背景情况:
- 循环分支链氨基酸 (BCAA) 与代谢综合征的组成部分有关,如肥胖,葡萄糖受损,胰岛素抵抗,高血压和脂质失调.
- 关于功能与循环中的BCAA水平之间的关系的数据有限.
- 这项研究调查了巴西成年人BCAA水平和功能标志物之间的关联.
研究的目的:
- 为了检查循环分支链氨基酸 (BCAA) 和估计的淋巴细胞过率 (eGFR) 之间的关联.
- 调查循环中的BCAA与蛋白-肌素比率 (ACR),这是损伤的标志物之间的关联.
- 为了探索巴西成年人纵向研究 (ELSA-巴西) 队列中的这些关联.
主要方法:
- 从ELSA-巴西研究中分析了4912名参与者,使用核磁共振进行了基线BCAA测量 (氨酸,异氨酸,白氨酸).
- 使用CKD-EPI方程 (不包括种族) 和12h-专蛋白-肌素比率 (ACR) 评估估计的淋巴膜过率 (eGFR).
- 构建未调整和调整的多变量线性回归模型,以评估总和个体BCAA水平与eGFR和ACR之间的关系.
主要成果:
- 在参与者中,GFR<60毫升/分钟/1.73平方米和ACR≥30毫克/克的参与者中,BCAA水平较高.
- 在人口调整后观察到BCAA水平和eGFR之间的初始反向关联,但在进一步的混调整后,这种情况没有持续下去.
- 发现BCAA水平与ACR≥30 mg/g之间存在正相关性,在调整后也没有证实这一点.
结论:
- 循环分支链氨基酸 (BCAA) 与估计的淋巴细胞过率 (eGFR) 有相反的关联,与专蛋白-肌素比率 (ACR) 有积极的关联.
- 这些关联需要进一步调查,以阐明潜在的机制和临床影响.
- 这些发现突出了BCAA代谢和脏健康之间的潜在联系,需要进一步的研究.
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