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在[¹⁷⁷Lu]Lu-DOTA-TATE治疗中的脏剂量测量基于多个小VOI

Selma Curkic Kapidzic¹, Johan Gustafsson², Erik Larsson³

¹Medical Radiation Physics, Lund, Lund University, Lund, Sweden; Radiation Physics, Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Sweden.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|March 31, 2024

概括

这项研究发现,在路铁-177 (Lu) DOTA-TATE治疗中使用多个小体积兴趣 (VOI) 进行脏剂量测量是准确的. 该方法提供可靠的活性度估计,以改善治疗规划.

科学领域:

核医学就是核医学.
医疗成像医学成像
放射性药物疗法是一种放射性药物疗法.

背景情况:

精确的剂量测量对于优化治疗疗效和最小化受体放射性核酸治疗 (PRRT) 中的毒性至关重要.
传统的剂量测量方法在准确的器官细分和活动量化方面可能面临挑战,特别是在部分体积效应方面.

研究的目的:

为了评估在Lu-DOTA-TATE治疗中使用多个感兴趣的小体积 (VOI) 进行脏剂量测量的有效性.
确定放置和分析这些小VOI的最佳方法,以确保准确的活性度 (AC) 测量.

主要方法:

使用了患者和模拟的SPECT图像在人类形状几何学,用OS-EM重建 (带/不带分辨率恢复) 使用LundaDose和Hermia程序.
确定了AC收的最佳代,并计算了2毫升VOI的回收系数 (RCs).
在使用五个小VOI以SPECT/CT (有/没有RR) 和单独CT为指导的AC估计中评估操作员变异性.

主要成果:

八个代和十个子集足以在重建程序和设置中实现AC融合.
恢复系数 (RCs) 与分辨率恢复 (RR) 有所不同;具有RR的值比没有 (0.91-0.94) 高 (0.91-1.10).
最稳定和准确的AC估计是使用5个2毫升的VOI以RR的SPECT/CT为指导,应用于没有RR的图像,并结合了明确的RC校正.

结论:

使用5个2毫升VOI的拟议方法在Lu-DOTA-TATE治疗中对脏剂量测量是高效且足够准确的.
这种方法为精确的活性度量化提供了可靠的替代方案,有可能改善治疗结果.

关键词:

(177) -PRRT 的时间.剂量测量方法剂量测量方法脏脏是什么?定量化 SPECT 是一个数量化 SPECT.

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