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在孤立的快速眼球运动睡眠行为障碍和帕金森病中,功能性大脑连接体

Florian Holtbernd¹, Christian Hohenfeld², Wolfgang H Oertel³

¹RWTH Aachen University, Department of Neurology, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Juelich Research Center GmbH and RWTH Aachen University, Aachen, Germany; Institute of Neuroscience and Medicine (INM-4/INM-11), Juelich Research Center, Juelich, Germany.

|March 31, 2024

概括

孤立的快速眼动行为障碍 (iRBD) 显示了广泛的功能性大脑改变,特别是在运动网络中,类似于帕金森病 (PD). 这些发现凸显了iRBD和PD之间共同的病理生理学,甚至在运动症状出现之前.

科学领域:

神经科学是一个神经科学.
神经学神经学
放射学放射学是一门学科.

背景情况:

孤立的快速眼动行为障碍 (iRBD) 通常在像帕金森病 (PD) 这样的同核蛋白病变之前.
以前的MRI研究发现iRBD的结构性大脑变化与PD相似.
在iRBD中,功能性大脑变化仍然不太了解.

研究的目的:

在iRBD中使用休息状态功能性MRI (rs-fMRI) 调查全脑功能连接.
为了比较iRBD患者的功能性脑连接组与帕金森病 (PD) 患者和健康对照组 (HC) 的功能性脑连接组.

主要方法:

从18名iRBD患者,18名PD患者和39名HC患者获得的rs-fMRI数据.
图形理论分析用于评估全球和区域大脑功能连接组.
用于数据分析的频率主义和贝叶斯统计方法.

主要成果:

全球功能连接在iRBD和PD组中一般保持.
无论是iRBD还是PD,都表现出运动,皮层 (包括边缘系统) 和视觉系统的局部连接性发生变化.
连接性变化在PD中更为明显,但在iRBD和PD之间观察到大量的重叠.

结论:

在iRBD中存在广泛的功能性大脑连接性改变,尽管正常的运动功能,但会影响运动电路.
在iRBD中观察到的连接体变化与PD中观察到的变化非常相似.
这些发现支持iRBD和PD之间的显著病理生理联系.

关键词:

功能性大脑连接组是功能性大脑连接组.功能性大脑成像 - 功能性脑成像图形理论是指图形的理论.这就是为什么MRI是MRI.帕金森病是帕金森氏症的一种疾病.雷姆睡眠行为障碍雷姆睡眠行为障碍

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