绘制创伤后应激障碍,抑郁症和酒精和大麻使用之间的途径:网络分析
Rachel E Williamson1, Kathryn S Macia2,3, Joshua Burton4
1Department of Psychology, University of Montana, Missoula, Montana, USA.
Journal of dual diagnosis
|March 31, 2024
概括
重度抑郁症 (MDD) 和创伤后应激障碍 (PTSD) 的症状可能会增加物质使用,有风险的行为可以弥合心理困扰和酒精/大麻使用. 大麻使用与酒精使用有关.
科学领域:
- 精神病学和行为科学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 创伤后应激障碍 (PTSD),主要抑郁障碍 (MDD) 和物质使用障碍的同时发生是常见的.
- 了解这些疾病之间的复杂相互作用和方向关系对于有效治疗至关重要.
- 之前的研究表明双向关系,但具体的途径仍然不清楚.
研究的目的:
- 调查网络结构并估计PTSD,MDD症状和酒精/大麻使用之间的定向路径.
- 识别关键的症状和行为,调解心理困扰和物质使用之间的关系.
主要方法:
- 利用贝叶斯网络分析,包括定向环形图 (DAG),对1471名美国成年人报告创伤事件的数据进行分析.
- 使用验证的工具:PTSD检查表 (PCL-5),患者健康问卷 (PHQ-9),以及酒精/大麻使用障碍识别测试 (AUDIT/CUDIT).
- 估计网络中心性和桥梁强度,以识别有影响力的症状及其连接.
主要成果:
- 症状的聚类与理论预期一致.
- 风险行为成为具有高桥梁强度的中心节点,将物质使用与PTSD联系起来.
- DAG的分析表明,MDD和PTSD症状预测了物质使用,而不是相反;酒精和大麻使用不是中央网络节点.
结论:
- 大麻使用与酒精使用密切相关.
- 风险行为作为物质使用和PTSD之间的重要桥梁,与先前的研究保持一致.
- 关联的方向性表明,心理症状可能会先于和影响物质使用,需要进一步调查.
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